Review: Ischemia Reperfusion Injury—A Translational Perspective in Organ Transplantation
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چکیده
منابع مشابه
Ischemia Reperfusion Injury in Kidney Transplantation
Ischemia and reperfusion have been a natural step during kidney transplantation. Impairment of blood flow starts with brain death due to severe hemodynamic disturbances in cadaveric donor. Clamping of renal artery causes an absolute ischemia during harvesting operation. Cold ischemia during allograft kidney storage may also cause additional ischemic damages (Southard et al. 1985; Ploeg et al.19...
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Ischemia-reperfusion injury to the kidney is a complex pathophysiological process that has importance during transplantation as it affects graft function and survival. It starts with the physiological changes associated with the death of the donor, including the direct effects of hypoxia and metabolic stress. The injury continues through the organ procurement and preservation procedures. Upon r...
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Ischemia reperfusion injury (IRI) is an inevitable clinical consequence in organ transplantation. It can lead to early graft nonfunction and contribute to acute and chronic graft rejection. Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therapies exist. This paper reviews factors involved in the pathophysiology of IRI and potential ways t...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21228549